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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DNASE2B All Species: 34.55
Human Site: S168 Identified Species: 63.33
UniProt: Q8WZ79 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8WZ79 NP_067056.2 361 41713 S168 T G R R N G Q S G I C I T F K
Chimpanzee Pan troglodytes XP_524754 357 41222 S164 T G R R N G Q S G I C I T F K
Rhesus Macaque Macaca mulatta XP_001106353 361 41660 S168 T G R R N G Q S G I C I T F K
Dog Lupus familis XP_537097 358 41217 T164 T G R R H G Q T G I C I T F K
Cat Felis silvestris
Mouse Mus musculus Q9QY48 354 40775 T161 S G R R Y G Q T G I C I T F G
Rat Rattus norvegicus Q9QZK9 356 40454 S163 S G R Q Y A Q S G L C I T L K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507235 348 37739 S157 T A R P K G Q S F L C V S F S
Chicken Gallus gallus NP_001032927 363 40865 T165 S G E S Y G Q T A I C I T F S
Frog Xenopus laevis NP_001086671 349 38720 C158 H N G Q S F L C V T Y P Y K Q
Zebra Danio Brachydanio rerio XP_691451 335 38242 T144 T G K Y Y G Q T L L C I T F N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650672 366 41322 K171 L K G E D L E K V G Q I L V Y
Honey Bee Apis mellifera XP_396933 375 42824 S180 S G T L Y G Q S F L C I S L G
Nematode Worm Caenorhab. elegans P34508 378 43329 S165 C I S Y N T V S L A T I A Q Q
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.6 97.5 83.3 N.A. 65.6 65 N.A. 38.2 53.9 39.6 44.8 N.A. 32.7 31.2 31.4 N.A.
Protein Similarity: 100 98.6 98.3 90.5 N.A. 77.8 77.8 N.A. 55.1 66.9 57.6 60.3 N.A. 51.9 51.7 50 N.A.
P-Site Identity: 100 100 100 86.6 N.A. 73.3 60 N.A. 46.6 53.3 0 53.3 N.A. 6.6 40 20 N.A.
P-Site Similarity: 100 100 100 100 N.A. 86.6 80 N.A. 66.6 66.6 20 73.3 N.A. 20 60 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 8 0 0 8 8 0 0 8 0 0 % A
% Cys: 8 0 0 0 0 0 0 8 0 0 77 0 0 0 0 % C
% Asp: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 8 8 0 0 8 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 8 0 0 16 0 0 0 0 62 0 % F
% Gly: 0 70 16 0 0 70 0 0 47 8 0 0 0 0 16 % G
% His: 8 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 0 47 0 85 0 0 0 % I
% Lys: 0 8 8 0 8 0 0 8 0 0 0 0 0 8 39 % K
% Leu: 8 0 0 8 0 8 8 0 16 31 0 0 8 16 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 0 0 31 0 0 0 0 0 0 0 0 0 8 % N
% Pro: 0 0 0 8 0 0 0 0 0 0 0 8 0 0 0 % P
% Gln: 0 0 0 16 0 0 77 0 0 0 8 0 0 8 16 % Q
% Arg: 0 0 54 39 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 31 0 8 8 8 0 0 54 0 0 0 0 16 0 16 % S
% Thr: 47 0 8 0 0 8 0 31 0 8 8 0 62 0 0 % T
% Val: 0 0 0 0 0 0 8 0 16 0 0 8 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 16 39 0 0 0 0 0 8 0 8 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _